We prove that in three of the classical turnover models in pharmacodynamics the time to maximal response increases with increasing drug dose when the concentration of the drug in the blood plasma decreases exponentially with time.
Nous démontrons que dans des trois modèles turnovers classiques en pharmacodynamique le temps de réponse maximal augmente en fonction de la dose de drogue lorsque la concentration du médicament dans le plasma sanguin diminue exponentiellement en temps.
Published online:
@article{CRMATH_2009__347_9-10_495_0,
author = {Nguyen, Hoai-Minh and Peletier, Lambertus A.},
title = {Monotonicity of the peak time in turnover models},
journal = {Comptes Rendus. Math\'ematique},
pages = {495--500},
publisher = {Elsevier},
volume = {347},
number = {9-10},
year = {2009},
doi = {10.1016/j.crma.2009.02.005},
language = {en},
url = {http://www.numdam.org/articles/10.1016/j.crma.2009.02.005/}
}
TY - JOUR AU - Nguyen, Hoai-Minh AU - Peletier, Lambertus A. TI - Monotonicity of the peak time in turnover models JO - Comptes Rendus. Mathématique PY - 2009 SP - 495 EP - 500 VL - 347 IS - 9-10 PB - Elsevier UR - http://www.numdam.org/articles/10.1016/j.crma.2009.02.005/ DO - 10.1016/j.crma.2009.02.005 LA - en ID - CRMATH_2009__347_9-10_495_0 ER -
%0 Journal Article %A Nguyen, Hoai-Minh %A Peletier, Lambertus A. %T Monotonicity of the peak time in turnover models %J Comptes Rendus. Mathématique %D 2009 %P 495-500 %V 347 %N 9-10 %I Elsevier %U http://www.numdam.org/articles/10.1016/j.crma.2009.02.005/ %R 10.1016/j.crma.2009.02.005 %G en %F CRMATH_2009__347_9-10_495_0
Nguyen, Hoai-Minh; Peletier, Lambertus A. Monotonicity of the peak time in turnover models. Comptes Rendus. Mathématique, Volume 347 (2009) no. 9-10, pp. 495-500. doi : 10.1016/j.crma.2009.02.005. http://www.numdam.org/articles/10.1016/j.crma.2009.02.005/
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