In this article, we consider the Cahn–Hilliard–Brinkman–Ohta–Kawasaki tumor growth system, which couples the Brinkman flow equations in the porous medium and the Cahn–Hilliard type equation with the nonlocal Ohta–Kawasaki term. We first construct a fully-decoupled discontinuous Galerkin method based on a decoupled, stabilized energy factorization approach and implicit-explicit Euler method in the time discretization, and strictly prove its unconditional energy stability. The optimal error estimate for the tumor interstitial fluid pressure is further obtained. Numerical results are also carried out to demonstrate the effectiveness of the proposed numerical scheme and verify the theoretical results. Finally, we apply the scheme to simulate the evolution of brain tumors based on patient-specific magnetic resonance imaging, and the obtained computational results show that the proposed numerical model and scheme can provide realistic calculations and predictions, thus providing an in-depth understanding of the mechanism of brain tumor growth.
Keywords: Cahn–Hilliard–Brinkman, fully-decoupled, discontinuous Galerkin method, error estimates, brain tumor growth
@article{M2AN_2022__56_6_2141_0,
author = {Zou, Guang-an and Wang, Bo and Yang, Xiaofeng},
title = {A fully-decoupled discontinuous {Galerkin} approximation of the {Cahn{\textendash}Hilliard{\textendash}Brinkman{\textendash}Ohta{\textendash}Kawasaki} tumor growth model},
journal = {ESAIM: Mathematical Modelling and Numerical Analysis },
pages = {2141--2180},
year = {2022},
publisher = {EDP-Sciences},
volume = {56},
number = {6},
doi = {10.1051/m2an/2022064},
mrnumber = {4516168},
language = {en},
url = {https://www.numdam.org/articles/10.1051/m2an/2022064/}
}
TY - JOUR AU - Zou, Guang-an AU - Wang, Bo AU - Yang, Xiaofeng TI - A fully-decoupled discontinuous Galerkin approximation of the Cahn–Hilliard–Brinkman–Ohta–Kawasaki tumor growth model JO - ESAIM: Mathematical Modelling and Numerical Analysis PY - 2022 SP - 2141 EP - 2180 VL - 56 IS - 6 PB - EDP-Sciences UR - https://www.numdam.org/articles/10.1051/m2an/2022064/ DO - 10.1051/m2an/2022064 LA - en ID - M2AN_2022__56_6_2141_0 ER -
%0 Journal Article %A Zou, Guang-an %A Wang, Bo %A Yang, Xiaofeng %T A fully-decoupled discontinuous Galerkin approximation of the Cahn–Hilliard–Brinkman–Ohta–Kawasaki tumor growth model %J ESAIM: Mathematical Modelling and Numerical Analysis %D 2022 %P 2141-2180 %V 56 %N 6 %I EDP-Sciences %U https://www.numdam.org/articles/10.1051/m2an/2022064/ %R 10.1051/m2an/2022064 %G en %F M2AN_2022__56_6_2141_0
Zou, Guang-an; Wang, Bo; Yang, Xiaofeng. A fully-decoupled discontinuous Galerkin approximation of the Cahn–Hilliard–Brinkman–Ohta–Kawasaki tumor growth model. ESAIM: Mathematical Modelling and Numerical Analysis , Tome 56 (2022) no. 6, pp. 2141-2180. doi: 10.1051/m2an/2022064
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