We consider a simple model for the immune system in which virus are able to undergo mutations and are in competition with leukocytes. These mutations are related to several other concepts which have been proposed in the literature like those of shape or of virulence - a continuous notion. For a given species, the system admits a globally attractive critical point. We prove that mutations do not affect this picture for small perturbations and under strong structural assumptions. Based on numerical and theoretical arguments, we also examine how, releasing these assumptions, the system can blow-up.

Classification: 34A34, 34G20, 70K20, 92D25, 92D10, 37A60

Keywords: virus dynamics, population dynamics, genetics, nonlinear integro-differential equations, nonlinear ordinary differential equations, dynamical systems in statistical mechanics, immunology, evolution theory

@article{M2AN_2003__37_4_709_0, author = {Frid, Hermano and Jabin, Pierre-Emmanuel and Perthame, Beno\^\i t}, title = {Global stability of steady solutions for a model in virus dynamics}, journal = {ESAIM: Mathematical Modelling and Numerical Analysis - Mod\'elisation Math\'ematique et Analyse Num\'erique}, publisher = {EDP-Sciences}, volume = {37}, number = {4}, year = {2003}, pages = {709-723}, doi = {10.1051/m2an:2003045}, zbl = {1065.92013}, mrnumber = {2018439}, language = {en}, url = {http://www.numdam.org/item/M2AN_2003__37_4_709_0} }

Frid, Hermano; Jabin, Pierre-Emmanuel; Perthame, Benoît. Global stability of steady solutions for a model in virus dynamics. ESAIM: Mathematical Modelling and Numerical Analysis - Modélisation Mathématique et Analyse Numérique, Volume 37 (2003) no. 4, pp. 709-723. doi : 10.1051/m2an:2003045. http://www.numdam.org/item/M2AN_2003__37_4_709_0/

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