A country-based review in COVID-19 related research developments

Modak, Nikunja Mohan; Sinha, Sudipta; Sana, Shib Sankar

RAIRO. Operations Research, Tome 56 (2022) no. 6, pp. 4191-4227

The COVID-19 pandemic has turned our life topsy-turvy. It has bought a massive change in all sectors around the world. A great number of research papers have already been published accounting for various aspects of the COVID-19 issue, owing to the ever-increasing interest in this hot area. The essential data is gathered using the well-known and dependable search engine SCOPUS. We looked at research papers, journals, and reviews from 25 leading countries to highlight a comprehensive study of research output through COVID-19 papers. This study focuses on the top authors, leading articles, and journals from various nations, the percentage of published papers in various fields, and the top collaborative research work from different authors and countries. USA, UK, China, Italy, and India have all made a significant contribution to COVID-19 research. The USA is the leading country followed by UK and China but for H-index China is in the best position. The highest number of papers has been developed in the area of "medicine". The Harvard Medical School of the UK contributed the highest number of papers followed by the University of Toronto of Canada. Professor K. Dhama of India has published the highest number of papers while C. Huang of China received the highest number of citations. It also highlights that several authors have differing opinions on the efficacy of taking the medicine remdesivir. Our research provides a complete and comprehensive image of the virus’s current research status, or in other words, a roadmap of the present research status.

Classification : 62Q05, 62P25, 62-02, 90-02
Keywords: COVID-19, pandemic, research, review, country analysis, scopus

[1] M. Ackermann, S. E. Verleden, M. Kuehnel, A. Haverich, T. Welte, F. Laenger, A. Vanstapel, C. Werlein, H. Stark, A. Tzankov and W. W. Li, Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in COVID-19. N. Engl. J. Med. 383 (2020) 120–128. | DOI

[2] T. Ai, Z. Yang, H. Hou, C. Zhan, C. Chen, W. Lv, Q. Tao, Z. Sun and L. Xia, Correlation of chest CT and RT-PCR testing for coronavirus disease 2019 (COVID-19) in China: a report of 1014 case. Radiology 296 (2020) E32–E40. | DOI

[3] N. S. Aydin, E. B. Tirkolaee, Modelling and predicting the growth dynamics of COVID-19 pandemic: a comparative study including Turkey, J. Turkish Oper. Manage. 6 (2022) 943–954.

[4] E. Babaee Tirkolaee and N. S. Aydın, A sustainable medical waste collection and transportation model for pandemics. Waste Manage. Res. 39 (2021) 34–44. | DOI

[5] J. J. V. Bavel, K. Baicker, P. S. Boggio, V. Capraro, A. Cichocka, M. Cikara, M. J. Crockett, A. J. Crum, K. M. Douglas, J. N. Druckman and J. Drury, Using social and behavioural science to support COVID-19 pandemic response. Nat. Human Behav. 4 (2020) 460–471. | DOI

[6] J. H. Beigel, K. M. Tomashek, L. E. Dodd, A. K. Mehta, B. S. Zingman, A. C. Kalil, E. Hohmann, H. Y. Chu, A. Luetkemeyer, S. Kline and D. Lopez De Castilla, Remdesivir for the treatment of COVID-19 – final report. N. Engl. J. Med. 383 (2020) 1813–1826. | DOI

[7] B. Bikdeli, M. V. Madhavan, D. Jimenez, T. Chuich, I. Dreyfus, E. Driggin, C. D. Nigoghossian, W. Ageno, M. Madjid, Y. Guo and L. V. Tang, COVID-19 and thrombotic or thromboembolic disease: implications for prevention, antithrombotic therapy, and follow-up: JACC state-of-the-art review. J. Am. College Cardiol. 75 (2020) 2950–2973. | DOI

[8] B. Cao, Y. Wang, D. Wen, W. Liu, J. Wang, G. Fan, L. Ruan, B. Song, Y. Cai, M. Wei and X. Li, A trial of lopinavir–ritonavir in adults hospitalized with severe COVID-19. N. Engl. J. Med. 382 (2020) 1787–1799. | DOI

[9] J. F. W. Chan, S. Yuan, K. H. Kok, K. K. W. To, H. Chu, J. Yang, F. Xing, J. Liu, C. C. Y. Yip, R. W. S. Poon and H. W. Tsoi, A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet 3952020 (2019) 514–523.

[10] N. Chen, M. Zhou, X. Dong, J. Qu, F. Gong, Y. Han, Y. Qiu, J. Wang, Y. Liu, Y. Wei and T. Yu, Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 395(2020) 507–513.

[11] M. Chinazzi, J. T. Davis, M. Ajelli, C. Gioannini, M. Litvinova, S. Merler, A. Pastore Y Piontti, K. Mu, L. Rossi, K. Sun and C. Viboud, The effect of travel restrictions on the spread of the 2019 novel coronavirus (COVID-19) outbreak. Science 368 (2020) 395–400. | DOI

[12] D. K. Chu, E. A. Akl, S. Duda, K. Solo, S. Yaacoub, H. J. Schünemann, A. El-Harakeh, A. Bognanni, T. Lotfi, M. Loeb and A. Hajizadeh, Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: a systematic review and meta-analysis. Lancet 395 (2020) 1973–1987. | DOI

[13] E. J. Emanuel, G. Persad, R. Upshur, B. Thome, M. Parker, A. Glickman, C. Zhang, C. Boyle, M. Smith and J. P. Phillips, Fair allocation of scarce medical resources in the time of COVID-19. N. Engl. J. Med. 382 (2020) 2049–2055. | DOI

[14] P. Gautret, J. Lagier, P. Parola, L. Meddeb, M. Mailhe, B. Doudier, J. Courjon, V. Giordanengo, V. E. Vieira, H. T. Dupont and S. Honoré, Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. Int. J. Antimicrob. Agents 56 (2020) 105949. | DOI

[15] A. H. Ghadir, H. R. Vandchali, M. Fallah and E. B. Tirkolaee, Evaluating the impacts of COVID-19 outbreak on supply chain risks by modified failure mode and effects analysis: a case study in an automotive company. Ann. Oper. Res. (2022) 1–31. DOI: . | DOI

[16] D. E. Gordon, G. M. Jang, M. Bouhaddou, J. Xu, K. Obernier, K. M. White, M. J. O’Meara, V. V. Rezelj, J. Z. Guo, D. L. Swaney and T. A. Tummino, A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature 583 (2020) 459–468. | DOI

[17] G. Grasselli, A. Zangrillo, A. Zanella, M. Antonelli, L. Cabrini, A. Castelli, D. Cereda, A. Coluccello, G. Foti, R. Fumagalli and G. Iotti, Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy region, Italy. JAMA – J. Am. Med. Assoc. 323 (2020) 1574–1581. | DOI

[18] J. Grein, N. Ohmagari, D. Shin, G. Diaz, E. Asperges, A. Castagna, T. Feldt, G. Green, M. L. Green, F. X. Lescure and E. Nicastri, Compassionate use of remdesivir for patients with severe COVID-19. N. Engl. J. Med. 382 (2020) 2327–2336. | DOI

[19] W. Guan, Z. Ni, Y. Hu, W. H. Liang, C. Q. Ou, J. X. He, L. Liu, H. Shan, C. L. Lei, D. S. Hui and B. Du, Clinical characteristics of coronavirus disease 2019 in China. N. Engl. J. Med. 382 (2020) 1708–1720. | DOI

[20] Y. R. Guo, Q. D. Cao, Z. S. Hong, Y. Y. Tan, S. D. Chen, H. J. Jin, K. S. Tan, D. Y. Wang and Y. Yan, The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak – an update on the status. Mil. Med. Res. 7 (2020) 1–10.

[21] J. Helms, C. Tacquard, F. Severac, I. Leonard-Lorant, M. Ohana, X. Delabranche, H. Merdji, R. Clere-Jehl, M. Schenck, F. Fagot Gandet and S. Fafi-Kremer, High risk of thrombosis in patients with severe SARS-CoV-2 infection: A multicenter prospective cohort study. Intensive Care Med. 46 (2020) 1089–1098. | DOI

[22] M. Hoffmann, H. Kleine-Weber, S. Schroeder, N. Krüger, T. Herrler, S. Erichsen, T. S. Schiergens, G. Herrler, N. H. Wu, A. Nitsche and M. A. Müller, SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell 181 (2020) 271–280. | DOI

[23] E. A. Holmes, R. C. O’Connor, V. H. Perry, I. Tracey, S. Wessely, L. Arseneault, C. Ballard, H. Christensen, R. C. Silver, I. Everall and T. Ford, Multidisciplinary research priorities for the COVID-19 pandemic: a call for action for mental health science. Lancet Psychiatry 7 (2020) 547–560. | DOI

[24] M. L. Holshue, C. Debolt, S. Lindquist, K. H. Lofy, J. Wiesman, H. Bruce, C. Spitters, K. Ericson, S. Wilkerson, A. Tural and G. Diaz, First case of 2019 novel coronavirus in the United States. N. Engl. J. Med. 382 (2020) 929–936. | DOI

[25] P. Horby, W. S. Lim, J. R. Emberson, M. Mafham, J. L. Bell, L. Linsell, N. Staplin, C. Brightling, A. Ustianowski, E. Elmahi, B. Prudon, C. Green, T. Felton, D. Chadwick, K. Rege, C. Fegan, L. C. Chappell, S. N. Faust, T. Jaki, K. Jeffery, A. Montgomery, K. Rowan, E. Juszczak, J. K. Baillie, R. Haynes and M. J. Landray, Dexamethasone in hospitalized patients with Covid-19 – preliminary report. N Engl J Med 384 (2021) 693–704. | DOI

[26] M. M. Hossain, S. A. Sarwar, E. L. J. Mckyer and P. Ma, Applications of artificial intelligence technologies in COVID-19 research: a bibliometric study. Preprints (2020). DOI: . | DOI

[27] C. Huang, Y. Wang, X. Li, L. Ren, J. Zhao, Y. Hu, L. Zhang, G. Fan, J. Xu, X. Gu and Z. Cheng, Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 395 (2020) 497–506. | DOI

[28] Z. Jin, X. Du, Y. Xu, Y. Deng, M. Liu, Y. Zhao, B. Zhang, X. Li, L. Zhang, C. Peng and Y. Duan, Structure of MPRO from SARS-CoV-2 and discovery of its inhibitors. Nature 582 (2020) 289–293. | DOI

[29] G. Kampf, D. Todt, S. Pfaender and E. Steinmann, Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents. J. Hospital Infection 104 (2020) 246–251. | DOI

[30] M. Kappi, M. C. Sab, B. S. Biradar and V. T. Bagalkoti, Bibliometric study of world COVID-19 publication output. Shanlax Int. J. Arts Sci. Humanities 8 (2021) 86–95. | DOI

[31] S. Khalilpourazari, H. H. Doulabi, A. Ö. Çiftçioğlu and G. W. Weber, Gradient-based grey wolf optimizer with Gaussian walk: application in modelling and prediction of the COVID-19 pandemic. Expert Syst. App. 177 (2021) 114920. | DOI

[32] J. Lai, S. Ma, Y. Wang, Z. Cai, J. Hu, N. Wei, J. Wu, H. Du, T. Chen, R. Li, H. Tan, L. Kang, L. Yao, M. Huang, H. Wang, G. Wang, Z. Liu and S. Hu, Factors associated with mental health outcomes among health care workers exposed to coronavirus disease 2019. JAMA Netw. Open 3 (2020) e203976.

[33] S. A. Lauer, K. H. Grantz, Q. Bi, F. K. Jones, Q. Zheng, H. R. Meredith, A. S. Azman, N. G. Reich and J. Lessler, The incubation period of coronavirus disease 2019 (COVID-19) from publicly reported confirmed cases: estimation and application. Ann. Intern. Med. 172 (2020) 577–582. | DOI

[34] J. R. Lechien, C. M. Chiesa-Estomba, D. R. De Siati, M. Horoi, S. D. Le Bon, A. Rodriguez, D. Dequanter, S. Blecic, F. El Afia, L. Distinguin and Y. Chekkoury-Idrissi, Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur. Arch. Oto-Rhino-Laryngol. 277 (2020) 2251–2261. | DOI

[35] Y. Liu, A. A. Gayle, A. Wilder-Smith and J. Rocklöv, The reproductive number of COVID-19 is higher compared to SARS coronavirus. J. Travel Med. 27 (2020) 1–4.

[36] R. Lu, X. Zhao, J. Li, P. Niu, B. Yang, H. Wu, W. Wang, H. Song, B. Huang, N. Zhu and Y. Bi, Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet 395 (2020) 565–574. | DOI

[37] L. Mao, H. Jin, M. Wang, Y. Hu, S. Chen, Q. He, J. Chang, C. Hong, Y. Zhou, D. Wang and X. Miao, Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol. 77 (2020) 683–690. | DOI

[38] A. Mondal and S. K. Roy, Multi-objective sustainable opened-and closed-loop supply chain under mixed uncertainty during COVID-19 pandemic situation, Comput. Ind. Eng. 159 (2021) 107453. | DOI

[39] M. Nicola, Z. Alsafi, C. Sohrabi, A. Kerwan, A. Al-Jabir, C. Iosifidis, M. Agha and R. Agha, The socio-economic implications of the coronavirus pandemic (COVID-19): a review. Int. J. Surgery 78 (2020) 185–193. | DOI

[40] F. P. Polack, S. J. Thomas, N. Kitchin, J. Absalon, A. Gurtman, S. Lockhart, J. L. Perez, G. P. Marc, E. D. Moreira, C. Zerbini and R. Bailey, Safety and efficacy of the BNT162b2 mRNA COVID-19 vaccine. N. Engl. J. Med. 383 (2020) 2603–2615. | DOI

[41] C. Qin, L. Zhou and Z. Hu, et al., Dysregulation of immune response in patients with coronavirus 2019 (COVID-19) in Wuhan, China. Clin. Infect. Dis. 71 (2020) 762–768. | DOI

[42] R. P. Rajkumar, COVID-19 and mental health: a review of the existing literature. Asian J. Psychiatry 52 (2020) 102066. | DOI

[43] A. Remuzzi and G. Remuzzi, COVID-19 and italy: what next? Lancet 395 (2020) 1225–1228. | DOI

[44] S. Richardson, J. S. Hirsch, M. Narasimhan, J. M. Crawford, T. Mcginn, K. W. Davidson, D. P. Barnaby, L. B. Becker, J. D. Chelico, S. L. Cohen and J. Cookingham, Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York city area. JAMA – J. Am. Med. Assoc. 323 (2020) 2052–2059. | DOI

[45] A. J. Rodriguez-Morales, J. A. Cardona-Ospina, E. Gutiérrez-Ocampo, E. Ocampo, R. Villamizar-Peña, Y. Holguin-Rivera, J. P. Escalera-Antezana, L. E. Alvarado-Arnez, D. K. Bonilla-Aldana, C. Franco-Paredes, A. F. Henao-Martinez and A. Paniz-Mondolfi, Clinical, laboratory and imaging features of COVID-19: a systematic review and meta-analysis. Travel Med. Infectious Dis. 34 (2020) 101623. | DOI

[46] H. A. Rothan and S. N. Byrareddy, The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J. Autoimmunity 109 (2020) 102433. | DOI

[47] T. Singhal, A review of coronavirus disease-2019 (COVID-19). Indian J. Pediatrics 87 (2020) 281–286. | DOI

[48] C. Sohrabi, Z. Alsafi, N. O’Neill, M. Khan, A. Kerwan, A. Al-Jabir, C. Iosifidis and R. Agha, World health organization declares global emergency: a review of the 2019 novel coronavirus (COVID-19). Int. J. Surgery 76 (2020) 71–76. | DOI

[49] M. Su, S. Xu and J. Weng, A bibliometric study of COVID-19 researches in Web of Science. Pharmacol. Res. 169 (2021) 105664. | DOI

[50] M. Z. Tay, C. M. Poh, L. Rénia, P. A. Macary and L. F. P. Ng, The trinity of COVID-19: immunity, inflammation and intervention. Nat. Rev. Immunol. 20 (2020) 363–374. | DOI

[51] E. B. Tirkolaee, A. Goli, P. Ghasemi and F. Goodarzian, Designing a sustainable closed-loop supply chain network of face masks during the COVID-19 pandemic: Pareto-based algorithms. J. Cleaner Prod. 333 (2022) 130056. | DOI

[52] N. Vasantha Raju and N. S. Harinarayana, Indian clinical trials on COVID-19: a review of clinical trials registry of India (CTRI) (2020). Available at SSRN 3674093. DOI: . | DOI

[53] Y. Wan, J. Shang, R. Graham, R. S. Baric and F. Li, Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS coronavirus. J. Virol. 94 (2020) e00127-20. | DOI

[54] Y. Wang, D. Zhang, G. Du, R. Du, J. Zhao, Y. Jin, S. Fu, L. Gao, Z. Cheng, Q. Lu and Y. Hu, Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial. Lancet 395 (2020) 1569–1578. | DOI

[55] W. J. Wiersinga, A. Rhodes, A. C. Cheng, S. J. Peacock and H. C. Prescott, Pathophysiology, transmission, diagnosis, and treatment of coronavirus disease 2019 (COVID-19): a review. JAMA – J. Am. Med. Assoc. 324 (2020) 782–793. | DOI

[56] R. Wölfel, V. M. Corman, W. Guggemos, M. Seilmaier, S. Zange, M. A. Müller, D. Niemeyer, T. C. Jones, P. Vollmar, C. Rothe and M. Hoelscher, Virological assessment of hospitalized patients with COVID-2019. Nature 581 (2020) 465–469. | DOI

[57] C. Wu, X. Chen, Y. Cai, X. Zhou, S. Xu, H. Huang, L. Zhang, X. Zhou, C. Du, Y. Zhang and J. Song, Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Internal Med. 1802020 (2019) 934–943.

[58] F. Wu, S. Zhao, B. Yu, Y. M. Chen, W. Wang, Z. G. Song, Y. Hu, Z. W. Tao, J. H. Tian, Y. Y. Pei and M. L. Yuan, A new coronavirus associated with human respiratory disease in China. Nature 579 (2020) 265–269. | DOI

[59] Z. Xu, L. Shi, Y. Wang, J. Zhang, L. Huang, C. Zhang, S. Liu, P. Zhao, H. Liu, L. Zhu and Y. Tai, Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respiratory Med. 8 (2020) 420–422. | DOI

[60] R. Yan, Y. Zhang, Y. Li, L. Xia, Y. Guo and Q. Zhou, Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Science 367 (2020) 1444–1448. | DOI

[61] L. Zhang, D. Lin, X. Sun, U. Curth, C. Drosten, L. Sauerhering, S. Becker, K. Rox and R. Hilgenfeld, Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved $\alpha$-ketoamide inhibitors. Science 368 (2020) 409–412. | DOI

[62] F. Zhou, T. Yu, R. Du, G. Fan, Y. Liu, Z. Liu, J. Xiang, Y. Wang, B. Song, X. Gu and L. Guan, Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 395 (2020) 1054–1062. | DOI

[63] P. Zhou, X. Yang, X. Wang, B. Hu, L. Zhang, W. Zhang, H. R. Si, Y. Zhu, B. Li, C. L. Huang and H. D. Chen, A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 579 (2020) 270–273. | DOI

[64] N. Zhu, D. Zhang, W. Wang, X. Li, B. Yang, J. Song, X. Zhao, B. Huang, W. Shi, R. Lu and P. Niu, A novel coronavirus from patients with pneumonia in China, 2019. N. Engl. J. Med. 382 (2020) 727–733. | DOI